Transcleral high resolution optical phase imaging of the retina (Conference Presentation)

Christophe Moser; Timothé Laforest; Laura Kowalczuk; Francine Behar-Cohen; Mathieu Künzi

doi:10.1117/12.2552923

11 March 2020 Transcleral high resolution optical phase imaging of the retina (Conference Presentation)

Christophe Moser, Timothé Laforest, Laura Kowalczuk, Francine Behar-Cohen, Mathieu Künzi

Proceedings Volume 11249, Quantitative Phase Imaging VI; 112490Z (2020) https://doi.org/10.1117/12.2552923
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

The retina is composed of several transparent layers of neuronal and glial cells active during the vision process. Several studies showed that their structure and density is impacted by numerous eye diseases, such as macular degeneration, glaucoma and retinis pigmentosa. Quantifying such small morphological changes in retinal cells at different depths is of considerable interest to understand the root cause of the diseases as well as to follow the efficacy of new therapeutic approaches. A widespread method to observe the retina ex-vivo at the cellular level is fluorescent confocal microscopy. However, a different imaging technique than fluorescence is required for in-vivo imaging in humans. We have shown that by using a combination of oblique illumination of the retina through the sclera, a phase image of the different layers can be generated and quantified.

Conference Presentation

Citation Download Citation

Christophe Moser, Timothé Laforest, Laura Kowalczuk, Francine Behar-Cohen, and Mathieu Künzi "Transcleral high resolution optical phase imaging of the retina (Conference Presentation)", Proc. SPIE 11249, Quantitative Phase Imaging VI, 112490Z (11 March 2020); https://doi.org/10.1117/12.2552923

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