Evaluation of the influence of buffer media on the colloidal stability of cadmium-free QDs stabilized with thioglycolic acid

Tatiana S. Ponomaryova; Anastasia S. Novikova; Alexey A. Sokolov; Irina Yu. Goryacheva

doi:10.1117/12.2625581

29 April 2022 Evaluation of the influence of buffer media on the colloidal stability of cadmium-free QDs stabilized with thioglycolic acid

Tatiana S. Ponomaryova, Anastasia S. Novikova, Alexey A. Sokolov, Irina Yu. Goryacheva

Author Affiliations +

Proceedings Volume 12194, Computational Biophysics and Nanobiophotonics; 121940X (2022) https://doi.org/10.1117/12.2625581
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

In this paper, we report on water synthesis with a selective size of AgInS/ZnS quantum dots (QDs) coated with thioglycolic acid and on the analysis of their colloidal stability in water and physiological saline buffers to assess their potential use as a fluorescent label in bioanalysis. Nine fractions of AgInS/ZnS hydrophilic QDs were dispersed in buffer solutions with a wide pH range (3.5–9.5) and investigated by measuring the fluorescence intensity and zeta potential. The results demonstrate the possibility of using water-soluble thioglycolic acid-coated QDs as a surface ligand for immunofluorescent labeling using commonly used buffers. The highest QD stability was observed in the pH range (6.0- 9.5).

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Tatiana S. Ponomaryova, Anastasia S. Novikova, Alexey A. Sokolov, and Irina Yu. Goryacheva "Evaluation of the influence of buffer media on the colloidal stability of cadmium-free QDs stabilized with thioglycolic acid", Proc. SPIE 12194, Computational Biophysics and Nanobiophotonics, 121940X (29 April 2022); https://doi.org/10.1117/12.2625581

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