Characterization of photobiophysical properties of sensitizers used in photodynamic therapy

Beate Roeder; Dirk U. Nather

doi:10.1117/12.48194

1 November 1991 Characterization of photobiophysical properties of sensitizers used in photodynamic therapy

Beate Roeder, Dirk U. Nather

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48194
Event: MedTech '91, 1991, Berlin, Germany

Abstract

Tetrapyrroles obtain very good photophysical properties making them efficient photosensitizers in photodynamic therapy. Most of them have high triplet quantum yields, long triplet lifetimes and triplet state energies suitable for singlet oxygen generation. These photophysical parameters differ depending on the chemical structure and interactions with the environment. Today a large variety of tetrapyrroles are synthetized or chemically separated from natural substances for investigation of their photophysical properties with the aim of using them in photodynamic therapy. In this paper, some general aspects of energy conversion and energy transfer of tetrapyrroles in relation to their photophysical and biophysical properties relevant for photodynamic activity are discussed. Essential optical methods for the investigation of these parameters, as well as the determination of segmental mobilities of sensitizer-carrier complexes, are discussed using the example of phthalocyanines.

Citation Download Citation

Beate Roeder and Dirk U. Nather "Characterization of photobiophysical properties of sensitizers used in photodynamic therapy", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48194

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