Ultrahigh-resolution polarization-sensitive optical coherence tomography

Michael Pircher; Erich Goetzinger; Rainer Andreas Leitgeb; Harald Sattmann; Christoph K. Hitzenberger

doi:10.1117/12.592700

13 April 2005 Ultrahigh-resolution polarization-sensitive optical coherence tomography

Michael Pircher, Erich Goetzinger, Rainer Andreas Leitgeb, Harald Sattmann, Christoph K. Hitzenberger

Proceedings Volume 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX; (2005) https://doi.org/10.1117/12.592700
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We present, to the best of our knowledge, the first ultrahigh resolution, polarization sensitive OCT images of human tissue in vivo. The system is based on a Mach Zehnder interferometer and a transversal scanning of the sample. A broadband superluminescent diode with a center wavelength of 897nm and a bandwidth (FWHM) of 155nm was used. The depth resolution of the system was measured with ~ 4 micrometer in air. The actual scanning speed of 1000 transversal lines per second enables the acquisition of an image (B-scan) consisting of 1600(x) x 1000(z) pixels in 1 second. The whole signal is recorded by a polarization sensitive detection unit at the interferometer exit which enables a phase resolved measurement. From the recorded data we were able to obtain backscattered intensity, retardation and cumulative fast axis orientation of the sample. Images of these parameters obtained from a technical sample and from a human cornea in vivo are presented.

Citation Download Citation

Michael Pircher, Erich Goetzinger, Rainer Andreas Leitgeb, Harald Sattmann, and Christoph K. Hitzenberger "Ultrahigh-resolution polarization-sensitive optical coherence tomography", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); https://doi.org/10.1117/12.592700

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