Ultra-high sensitivity nanoplasmonic resonance energy transfer spectroscopic biomolecular imaging

G. Logan Liu

doi:10.1117/12.819052

30 April 2009 Ultra-high sensitivity nanoplasmonic resonance energy transfer spectroscopic biomolecular imaging

G. Logan Liu

Proceedings Volume 7312, Advanced Environmental, Chemical, and Biological Sensing Technologies VI; 731204 (2009) https://doi.org/10.1117/12.819052
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

Nanoplasmonic resonance spectroscopy enhances sensitivity and throughput of conventional SPR detection technique while still suffers with modest molecular specificity. Here we demonstrated a new sensing technique --- nano plasmonic resonance energy transfer (PRET) spectroscopy to detect complex biomolecular activities including conformational change, electron transfer and protein interactions with ultrahigh sensitivity and specificity. Compared to FRET sensing technology, PRET has much stronger optical signal to noise ratio and minimal photobleaching problems. Nano PRET spectroscopic molecular imaging technique can be used in multiplexed label-free cancer biomarker detections and environmental sensing applications.

Citation Download Citation

G. Logan Liu "Ultra-high sensitivity nanoplasmonic resonance energy transfer spectroscopic biomolecular imaging", Proc. SPIE 7312, Advanced Environmental, Chemical, and Biological Sensing Technologies VI, 731204 (30 April 2009); https://doi.org/10.1117/12.819052

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