Three-dimensional intracellular motility imaging in non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography

Pradipta Mukherjee; Shinichi Fukuda; Donny Lukmanto; Toshiharu Yamashita; Kosuke Okada; Ibrahim Abd El-Sadek; Arata Miyazawa; Lida Zhu; Shuichi Makita; Tetsuro Oshika; Yoshiaki Yasuno

doi:10.1117/12.2611984

7 March 2022 Three-dimensional intracellular motility imaging in non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno

Author Affiliations +

Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC119480S (2022) https://doi.org/10.1117/12.2611984
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present 3D intracellular motility imaging in MCD-diet induced non-alcoholic fatty liver disease (NAFLD) model by OCT-based dynamics imaging method, logarithmic intensity variance (LIV). LIV imaging visualizes the label-free intracellular activity. A 1-week and 2-week NAFLD model were investigated. In 1-week NAFLD, formation of large number of highly dynamic small particles at the beneath of the tissue surface were observed in LIV volume rendering image. In 2-week NAFLD model, a thin high LIV layer signal appeared in cross-sectional LIV image just beneath the tissue surface. The LIV projection and volume rendering images also reveal several discontinuous vessel-like structures.

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Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Shuichi Makita, Tetsuro Oshika, and Yoshiaki Yasuno "Three-dimensional intracellular motility imaging in non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119480S (7 March 2022); https://doi.org/10.1117/12.2611984

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