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4 October 2022 SERS for molecular information of mitochondria in the live cell (Conference Presentation)
Dong-Kwon Lim
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Proceedings Volume PC12203, Enhanced Spectroscopies and Nanoimaging 2022; PC122030B (2022) https://doi.org/10.1117/12.2632593
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States
Abstract
SERS have been attracted as a bioanalytical tool by utilizing plasmonic nanomaterials to enhance the intensity of Raman scattering. Two different analytes such as nucleic acid target or natural biomolecules inside single cell have been investigated in our research group. For nucleic acid target, it is inevitable for the use of surrogate to determine the presence of specific nucleic acid target. Our recent study showed that SERS is superior to assay performance of fluorescence-based assay (Sensors and Actuators B: Chemical Volume 329, 15 February 2021, 129134, ACS Appl. Mater. Interfaces 2022, 14, 1, 138–149). Instead obtaining the Raman signals from surrogate, obtaining molecular information from the cell is also interesting and meaningful applications. For this purpose, we investigated the molecular signals of mitochondria with mitochondria targeting AuNPs and Raman analysis for single live cell. Diverse changes of molecular signals could be obtained depends on the type of stimulus such as chemical or physical. In this talk, I will focus on the recent progress studied in this area (ACS omega 4 (5), 8188-8195, Nanoscale Advances 3 (12), 3470-3480).
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© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Dong-Kwon Lim "SERS for molecular information of mitochondria in the live cell (Conference Presentation)", Proc. SPIE PC12203, Enhanced Spectroscopies and Nanoimaging 2022, PC122030B (4 October 2022); https://doi.org/10.1117/12.2632593
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KEYWORDS
Raman spectroscopy
Actuators
Analytical research
Biological research
Chemical analysis
Interfaces
Nanomaterials
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