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This paper proposes a fast whole-organ histological imaging method with real-time staining and mechanical sectioning. Time-consuming and laborious sample processing procedures are not needed. The imaged tissue block will be labeled along with the serial sectioning and optical scanning to improve the overall speed and the uniformity of staining. A super-resolution network (ESRGAN) and an optical-sectioning imaging technique (HiLo microscopy) have been applied to optimize the imaging speed and resolution. The proposed system can realize whole-organ histological imaging within hours to days, depending on the volume of the imaged sample.
Wentao Yu,Yan Zhang,Lei Kang,Claudia T. K. Lo, andTerence T. W. Wong
"Rapid block-face serial sectioning tomography for automated three-dimensional histological imaging (Conference Presentation)", Proc. SPIE PC12385, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXX, PC1238502 (15 March 2023); https://doi.org/10.1117/12.2647791
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Wentao Yu, Yan Zhang, Lei Kang, Claudia T. K. Lo, Terence T. W. Wong, "Rapid block-face serial sectioning tomography for automated three-dimensional histological imaging (Conference Presentation)," Proc. SPIE PC12385, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXX, PC1238502 (15 March 2023); https://doi.org/10.1117/12.2647791