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26 April 2023 Chemical specific orientation imaging through vibrational sum-frequency generation microscopy and machine learning
Jackson Wagner, Zishan Wu, Wei Xiong
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Proceedings Volume PC12390, High-Speed Biomedical Imaging and Spectroscopy VIII; PC1239006 (2023) https://doi.org/10.1117/12.2656537
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Molecular self-assembled (MSA) materials such as lipid membranes, collagen, and DNA are common in living organisms and their hierarchical organization is crucial to the ultimate function of many biological systems. To understand the structure-properties correlations of MSA, it is necessary to characterize the micro-level structures and to obtain the chemical information simultaneously. To address this challenge, we coupled polarization resolved collinear vibrational sum frequency generation spectroscopy, an interface and symmetry selective second order nonlinear optical technique, with a line scanning microscopy platform to create a line scanning VSFG hyperspectral microscope which characterizes different chemical environment with spatial fidelity. The microscope was applied to a biomimetic MSA comprised of β-cyclodextrin (β-CD), a cup shaped heptamer of glucose, and sodium dodecyl sulfate (SDS), a common surfactant.
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Jackson Wagner, Zishan Wu, and Wei Xiong "Chemical specific orientation imaging through vibrational sum-frequency generation microscopy and machine learning", Proc. SPIE PC12390, High-Speed Biomedical Imaging and Spectroscopy VIII, PC1239006 (26 April 2023); https://doi.org/10.1117/12.2656537
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KEYWORDS
Microscopes
Imaging spectroscopy
Machine learning
Microscopy
Sum-frequency generation
Charge-coupled devices
Reflectivity
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