Presentation
16 March 2023 Non-invasive and label-free zebrafish investigations using polarization-sensitive optical coherence tomography (Conference Presentation)
Author Affiliations +
Abstract
The zebrafish has shown to be an essential preclinical animal model, especially in the field of oncology. A non-invasive, high-resolution, and three-dimensional imaging modality is required to identify disease related changes in this model organism. The presented polarization-sensitive Jones matrix optical coherence tomography (JM-OCT) prototype was utilized in three different studies, covering in vivo imaging of wildtype zebrafish, an adult postmortem tumor model and a longitudinal xenograft tumor zebrafish investigation. This work highlights the potential of JM-OCT as a non-invasive, label-free, and three-dimensional imaging tool for preclinical cancer research based on zebrafish models.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Antonia Lichtenegger, Junya Tamaoki, Pradipta Mukherjee, Roxane Licandro, Lida Zhu, Tomoko Mori, Rion Morishita, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Satoshi Matsusaka, Martin Distel, Makoto Kobayashi, Bernhard Baumann, and Yoshiaki Yasuno "Non-invasive and label-free zebrafish investigations using polarization-sensitive optical coherence tomography (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910Z (16 March 2023); https://doi.org/10.1117/12.2646760
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KEYWORDS
Optical coherence tomography

3D image processing

3D modeling

Polarization

Prototyping

Tumors

Image resolution

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