13 March 2024Detecting Barrett’s esophagus using a methylene blue fluorescent slurry and a multi-modal optical coherence tomography and fluorescence capsule
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We conducted a first-in-human study using a fluorescent slurry comprised of 10 ml Methylene Blue (50 mg dissolved in water) and 10 ml Agave nectar. Preliminary data from the first patient indicates that at 20 minutes Barrett's Esophagus (esophageal pre-cancer) can be discriminated from normal tissue with a target-to-background ratio of 1.96 and an effect size > 5 (Cohen's D). We further show a dose modification pathway to high-TBR imaging shortly after swallowing the slurry.
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Andrew D. Thrapp, Evaggelia Gavgiotakis, Joseph A. Gardecki, Andreas Wartak, Catriona N. Grant, Guillermo J. Tearney, "Detecting Barrett’s esophagus using a methylene blue fluorescent slurry and a multi-modal optical coherence tomography and fluorescence capsule," Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282006 (13 March 2024); https://doi.org/10.1117/12.3008546