Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy

G. Tsiminis; E. P. Schartner; J. L. Brooks; M. R. Hutchinson

doi:10.1117/12.2244620

9 December 2016 Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy

G. Tsiminis, E. P. Schartner, J. L. Brooks, M. R. Hutchinson

Author Affiliations +

Proceedings Volume 10013, SPIE BioPhotonics Australasia; 100130M (2016) https://doi.org/10.1117/12.2244620
Event: SPIE BioPhotonics Australasia, 2016, Adelaide, Australia

Abstract

Vitamin B12 (cobalamin and its derivatives) deficiency has been identified as a potential modifiable risk factor for dementia and Alzheimer’s disease. Chronic deficiency of vitamin B12 has been significantly associated with an increased risk of cognitive decline. An effective and efficient method for measuring vitamin B12 concentration in human blood would enable ongoing tracking and assessment of this potential modifiable risk factor. In this work we present an optical sensor based on resonance Raman spectroscopy for rapid measurements of vitamin B12 in human blood serum. The measurement takes less than a minute and requires minimum preparation (centrifuging) of the collected blood samples.

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G. Tsiminis, E. P. Schartner, J. L. Brooks, and M. R. Hutchinson "Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100130M (9 December 2016); https://doi.org/10.1117/12.2244620

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