Fabry-Pérot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment

Charusluk Viphavakit; DineshBabu Duraibabu; Sinead O'Keeffe; Elfed Lewis

doi:10.1117/12.2265084

23 April 2017 Fabry-Pérot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment

Charusluk Viphavakit, DineshBabu Duraibabu, Sinead O'Keeffe, Elfed Lewis

Author Affiliations +

Proceedings Volume 10323, 25th International Conference on Optical Fiber Sensors; 103233K (2017) https://doi.org/10.1117/12.2265084
Event: 25th International Conference on Optical Fiber Sensors, 2017, Jeju, Korea, Republic of

Abstract

An optical fiber sensor based on Fabry-Pérot interferometer to measure the refractive index changes due to oxygenation level changes in hypoxic tumors for radiotherapy treatments is proposed. The sensors have an outer diameter of 220μm with a 20-30μm length air-cavity and a 30μm thickness end cap located at the tip of the sensor. The sensors are used to measure the phase change in the received optical spectrum when there is a change in refractive index using a Fast Fourier Transform based analysis method. The refractive index change is measured in order to determine the oxygenation level in hypoxic tumors. In this paper, different concentrations of iso-propanol solution are prepared to produce refractive index values between 1.3438 and 1.3655 in order to mimic the refractive index of hemoglobin. The sensors are coated with a 100 nm thick gold layer and a comparison is made with non-coated sensors. The coated sensors have a resolution in order of 10^-3 RIU.

Citation Download Citation

Charusluk Viphavakit, DineshBabu Duraibabu, Sinead O'Keeffe, and Elfed Lewis "Fabry-Pérot based refractive index optical fiber sensor for measurement of oxygen concentration levels in hypoxic tumors during radiotherapy treatment", Proc. SPIE 10323, 25th International Conference on Optical Fiber Sensors, 103233K (23 April 2017); https://doi.org/10.1117/12.2265084

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