Investigation of vascular scattering patterns in retinal and choroidal OCT angiography with a contrast agent (Conference Presentation)

Marcel Bernucci; Conrad W. Merkle; Vivek J. Srinivasan

doi:10.1117/12.2286981

5 April 2018 Investigation of vascular scattering patterns in retinal and choroidal OCT angiography with a contrast agent (Conference Presentation)

Marcel Bernucci, Conrad W. Merkle, Vivek J. Srinivasan

Author Affiliations +

Proceedings Volume 10474, Ophthalmic Technologies XXVIII; 1047404 (2018) https://doi.org/10.1117/12.2286981
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Optical Coherence Tomography Angiography (OCTA) has recently emerged for imaging vasculature in clinical ophthalmology. Yet, apparent OCTA image artifacts remain challenging to interpret. Here, contrast-enhanced OCTA is employed in rats to help explain these apparent artifacts. By quantifying enhancement due to an intravascular contrast agent with rheological and scattering properties that are different from red blood cells (RBCs), OCTA image features are ascribed to specific rheological and scattering properties of RBCs. By imaging pigmented and unpigmented rats at a wavelength where scattering dominates image contrast (1300 nm), the impact of melanosome scattering on OCT and OCTA signals is determined.

Conference Presentation

Citation Download Citation

Marcel Bernucci, Conrad W. Merkle, and Vivek J. Srinivasan "Investigation of vascular scattering patterns in retinal and choroidal OCT angiography with a contrast agent (Conference Presentation)", Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 1047404 (5 April 2018); https://doi.org/10.1117/12.2286981

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