Combined photothermo-chemotherapy using gold nanoshells on drug-loaded micelles for colorectal cancer treatment

Shin-Yu Lee; Ming-Jium Shieh

doi:10.1117/12.2287184

23 February 2018 Combined photothermo-chemotherapy using gold nanoshells on drug-loaded micelles for colorectal cancer treatment

Shin-Yu Lee, Ming-Jium Shieh

Author Affiliations +

Proceedings Volume 10507, Colloidal Nanoparticles for Biomedical Applications XIII; 105070Y (2018) https://doi.org/10.1117/12.2287184
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Combined photothermo-chemotherapy is a new strategy for cancer treatment which improves the therapeutic outcome by synergistic effects of both therapies. Here, we presented a multifunctional gold nanoshell that exhibited excellent photothermal conversion and delivered the hydrophobic chemotherapy drug, SN-38. The positively charged SN-38-loaded PDMA-PCL micelles were decorated with a gold layer by in situ reduction of chloroauric acid on the surface of micelles. Scanning and transmission electron microscopy images proved micelles were successfully decorated and the resulting gold nanoshells had a spherical morphology with a narrow size distribution. The synthesized gold nanoshells displayed a broad surface plasmon resonance peak in the near-infrared wavelength region and a great photothermal conversion ability. After pegylation, gold nanoshells were stable in biological media and appeared highly biocompatible in the absence of laser irradiation. Upon near-infrared laser irradiation, incident energy was converted into heat by gold nanoshells on SN-38-loaded micelles (SN-38@pGNS), which causes local temperature increase and triggers the release of encapsulated drug. Compared to SN-38, SN-38-loaded micelles, or laser with drug-free gold nanoshells alone, combined photothermo-chemotherapy using SN-38@pGNS with laser irradiation killed colorectal cancer cells with higher efficacy in vitro and demonstrated significant tumor suppression in vivo, suggesting that gold nanoshells on drug-loaded micelles delivered SN-38 and photothermal therapy in synergistic actions and might be a potential candidate for future colorectal cancer therapy.

Citation Download Citation

Shin-Yu Lee and Ming-Jium Shieh "Combined photothermo-chemotherapy using gold nanoshells on drug-loaded micelles for colorectal cancer treatment", Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 105070Y (23 February 2018); https://doi.org/10.1117/12.2287184

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