Visible resonance Raman spectroscopy detect key molecular biomarker  vibrations to characterize for human brain gliomas

Yan Zhou M.D.; Cheng-hui Liu; Binlin Wu; Xinguang Yu M.D.; Gangge Cheng M.D.; Chunyuan Zhang; Hong Chen; Shenglin Li; Rui Zong M.D.; Qijun Liang; Ce Zhang; Mingqian Zhang; Cuicui Lu; Ke Zhu; Robert R. Alfano

doi:10.1117/12.2318751

24 April 2018 Visible resonance Raman spectroscopy detect key molecular biomarker vibrations to characterize for human brain gliomas

Yan Zhou M.D., Cheng-hui Liu, Binlin Wu, Xinguang Yu M.D., Gangge Cheng M.D., Chunyuan Zhang, Hong Chen, Shenglin Li, Rui Zong M.D., Qijun Liang, Ce Zhang, Mingqian Zhang, Cuicui Lu, Ke Zhu, Robert R. Alfano

Author Affiliations +

Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 107110O (2018) https://doi.org/10.1117/12.2318751
Event: SPIE Structured Light, 2018, Yokohama, Japan

Abstract

Visible resonant Raman (VRR) spectroscopy provides an effective way to enhance Raman signal from particular bonds associated with key molecules due to changes on molecular level. This paper reports on the VRR use for detection of human brain the control and gliomas of three grades. From the RR spectra additional two molecular vibrational biomarkers at 1129cm^-1 and 1338cm^-1, for the four types of brain tissues are significantly different in intensity. The new RR spectral peaks can be used as molecular biomarkers to evaluate glioma grades and identify the margin of gliomas from the controls. The metabolic process of glioma cells based on the RR spectral changes may reveal the Warburg hypothesis.

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Yan Zhou M.D., Cheng-hui Liu, Binlin Wu, Xinguang Yu M.D., Gangge Cheng M.D., Chunyuan Zhang, Hong Chen, Shenglin Li, Rui Zong M.D., Qijun Liang, Ce Zhang, Mingqian Zhang, Cuicui Lu, Ke Zhu, and Robert R. Alfano "Visible resonance Raman spectroscopy detect key molecular biomarker vibrations to characterize for human brain gliomas", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107110O (24 April 2018); https://doi.org/10.1117/12.2318751

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