Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance

O. Semyachkina-Glushkovskaya; M. Klimova; E. Duarte Torres; A. Khorovodov; A. Terskov; A. Mamedova; A. E. Shareef; E. Saranceva; T. Iskra; A. Pavlov; J. Kurths

doi:10.1117/12.2508259

4 March 2019 Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance

O. Semyachkina-Glushkovskaya, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Terskov, A. Mamedova, A. E. Shareef, E. Saranceva, T. Iskra, A. Pavlov, J. Kurths

Author Affiliations +

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790C (2019) https://doi.org/10.1117/12.2508259
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Stroke and traumatic brain injury are often associated with formation of brain edema, which is a potentially fatal pathological state provoking extensive accumulation of fluid in the brain tissues resulting in elevation of intracranial pressure and leading to impaired nerve function. There is only symptomatic anti-edema therapy is currently available. Therefore, the development of novel strategies to remove edema fluid is required. The brain edema is classified as vasogenic or cytotoxic edema, which associated with excess accumulation of fluid (edema) around capillaries resulting from disruption of the blood-brain barrier (BBB) or intracellular spaces (cell swelling) of the brain, respectively. In this brief review, we discuss possible mechanisms underlying brain edema formation and new strategies in development of novel of anti-edema drugs.

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O. Semyachkina-Glushkovskaya, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Terskov, A. Mamedova, A. E. Shareef, E. Saranceva, T. Iskra, A. Pavlov, and J. Kurths "Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790C (4 March 2019); https://doi.org/10.1117/12.2508259

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