Multiband terahertz imaging simulation of skin using freezing to enhance penetration depth

Zoltan Vilagosh M.D.; Alireza Lajevardipour; Andrew W. Wood

doi:10.1117/12.2512342

1 March 2019 Multiband terahertz imaging simulation of skin using freezing to enhance penetration depth

Zoltan Vilagosh M.D., Alireza Lajevardipour, Andrew W. Wood

Proceedings Volume 10948, Medical Imaging 2019: Physics of Medical Imaging; 109483S (2019) https://doi.org/10.1117/12.2512342
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

The Terahertz (THz) frequency region of the electromagnetic spectrum is defined as radiation of 0.1 to 10.0 x 10¹² Hz. A unique feature of the 0.1 to 2.0 THz frequency band is that there is a high disparity between liquid water and ice absorption, with ice being 100 times more permeable to THz radiation. The high absorption by liquid water limits the deployment of 0.1 to 2.0 THz band for imaging and therapeutics to 0.2-0.3 mm in soft tissues. By freezing tissue, however, an imaging depth of 5.0 mm is achievable. Computational finite difference time domain (FDTD) modelling was undertaken using realistic tissue phantoms to explore this enhanced depth for imaging of frozen skin lesions such as melanomas. The computational modeling confirms that there is adequate contrast between normal frozen skin and pathological lesions. The imaging is enhanced by sampling the frozen tissue at both 0.45 and 1.00 THz. A method of analysing the data in a simplified, systematic way is introduced by dividing the returning signal into time regions and comparing their relative intensity. The concept will be developed into a “THz eye”, where the differences in THz absorption and refraction of tissues between individual THz frequencies are exploited for superior imaging.

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Zoltan Vilagosh M.D., Alireza Lajevardipour, and Andrew W. Wood "Multiband terahertz imaging simulation of skin using freezing to enhance penetration depth", Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109483S (1 March 2019); https://doi.org/10.1117/12.2512342

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KEYWORDS

Terahertz radiation

Skin

Absorption

Water

Tissues

Picosecond phenomena

Reflection

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