Optofluidic microstructured fibers: detecting freely diffusing nanoobjects via dynamic light scattering (Conference Presentation)

Markus A. Schmidt

doi:10.1117/12.2525384

14 May 2019 Optofluidic microstructured fibers: detecting freely diffusing nanoobjects via dynamic light scattering (Conference Presentation)

Markus A. Schmidt

Author Affiliations +

Proceedings Volume 11029, Micro-structured and Specialty Optical Fibres VI; 1102905 (2019) https://doi.org/10.1117/12.2525384
Event: SPIE Optics + Optoelectronics, 2019, Prague, Czech Republic

Abstract

High-speed tracking of single nanoobjects is a gateway to understanding physical, chemical, and biological processes at the nanoscale. Here I will present our recent results on tracking single individual nanoobjects inside optofluidic optical fibers via elastic light scattering. The nanoobjects are located within an aqueous environment inside a well-selected channel of microstructured optical fiber. Light from the core mode which hits the freely diffusing nano-object scatters off and can be detected transversely. Tracking of unlabeled dielectric particles as small as 20 nm as well as individual cowpea chlorotic mottle virus (CCMV) virions at rates of over 2 kHz for durations of tens of seconds has been achieved in nanobore optical fibers, whereas full 3D information about the nano-object’s trajectory are retrieved in modified step index fibers. From the light scattering intensities and the diffusion constants we were able to determine key properties of the particles such as size or hydrodynamic radius.

Conference Presentation

Citation Download Citation

Markus A. Schmidt "Optofluidic microstructured fibers: detecting freely diffusing nanoobjects via dynamic light scattering (Conference Presentation)", Proc. SPIE 11029, Micro-structured and Specialty Optical Fibres VI, 1102905 (14 May 2019); https://doi.org/10.1117/12.2525384

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