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Since 1978 the initial research on PDTand PDD using canine lung cancer model and then clinical research of early stage cancers of lung, esophagus, stomach and cervix was performed with hematoporphyrin derivative and argon dye laser. A lot of meetings on PRT which was called initially, mainly in USA, Late in 1980's IPA was founded during the International Meeting of Clinical Application of PRT in Tokyo. After the extended clinical trials of PDT on early stage cancers by the support of Government in 1980' Japanese Government approved PDT with Photofrin and argon dye laser or excimer dye laser for clinical use in 1992. A New photosensitizer of Laserphyrin (
Chrolin e6) wad developed after the preclinical investigation by Prof. David Kessel. This photosensitizer showed less skin photosensitibity than previous Photofrin.
Harubumi Kato
"Clinical application: PDT with Tom Dougherty (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107019 (14 August 2019); https://doi.org/10.1117/12.2525955
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Harubumi Kato, "Clinical application: PDT with Tom Dougherty (Conference Presentation)," Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107019 (14 August 2019); https://doi.org/10.1117/12.2525955