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14 August 2019 Photodynamic therapy of brain tumor stem cells overcomes drug-resistance in preclinical models (Conference Presentation)
Bryan Q. Spring
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Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110701E (2019) https://doi.org/10.1117/12.2527769
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States
Abstract
Standard chemoradiation often enriches drug-resistant tumor cell populations that can lead to recurrent and treatment-refractory disease. For instance, preclinical models of several cancers suggest that the cancer stem cell subpopulation becomes enriched and re-populates the tumor milieu following conventional therapies. Here, we show evidence that photodynamic therapy (PDT) is effective against several patient-derived glioblastoma stem cell cultures. Moreover, sub-lethal PDT results in re-sensitization of cancer cell phenotypes with induced drug-resistance to chemotherapy. This talk will also introduce some of our efforts to establish a new program aimed at developing personalized and targeted PDT to overcome drug-resistance.
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Bryan Q. Spring "Photodynamic therapy of brain tumor stem cells overcomes drug-resistance in preclinical models (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701E (14 August 2019); https://doi.org/10.1117/12.2527769
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KEYWORDS
Photodynamic therapy
Stem cells
Tumors
Brain
Cancer
Therapeutics
Tumor growth modeling
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