Estimation of spectroscopic attenuation coefficient in retinal nerve fiber layer for detection of glaucoma (Conference Presentation)

Shuang Chang; Theodore Leng; Sylvia Groth; Audrey K. Bowden

doi:10.1117/12.2546057

9 March 2020 Estimation of spectroscopic attenuation coefficient in retinal nerve fiber layer for detection of glaucoma (Conference Presentation)

Shuang Chang, Theodore Leng, Sylvia Groth, Audrey K. Bowden

Author Affiliations +

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112340S (2020) https://doi.org/10.1117/12.2546057
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In glaucoma, degeneration occurs in the retinal ganglion cells, whose cell bodies reside in the retinal nerve fiber layer (RNFL), leading to a decrease in the RNFL thickness. In clinical practice, optical coherence tomography (OCT) is used to measure the RNFL thickness for glaucoma diagnosis. Recent studies have shown that the degenerative process induces changes in optical properties of the RNFL, such as reflectivity. Because such properties can also be determined with OCT, we quantify this reduced scattering effect by determining spectroscopic attenuation coefficient (AC) in the RNFL with our proprietary autoConfoal algorithm, from two OCT B-scans of glaucomatous eyes.

Conference Presentation

Citation Download Citation

Shuang Chang, Theodore Leng, Sylvia Groth, and Audrey K. Bowden "Estimation of spectroscopic attenuation coefficient in retinal nerve fiber layer for detection of glaucoma (Conference Presentation)", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340S (9 March 2020); https://doi.org/10.1117/12.2546057

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