Optical evaluation of microvascular function at early and chronic stages of diabetes

Shotaro Sasaki; Mikie Nakabayashi; Yumie Ono; Masashi Ichinose

doi:10.1117/12.2545267

21 February 2020 Optical evaluation of microvascular function at early and chronic stages of diabetes

Shotaro Sasaki, Mikie Nakabayashi, Yumie Ono, Masashi Ichinose

Author Affiliations +

Proceedings Volume 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables; 112370R (2020) https://doi.org/10.1117/12.2545267
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We investigated blood flow response for reactive hyperemia test in type1 diabetic and control rats using diffuse correlation spectroscopy (DCS). The baseline blood flow, peak amplitude and time to peak blood flow responses after releasing from ischemia were significantly decreased after induction of hyperglycemic state in diabetic rats. Furthermore, the baseline blood flow and the peak amplitude were significantly decreased from 1st week to 10th week in diabetic rats, suggesting the progress of vascular dysfunction caused by sustained glycemic stress. This research showed a potential of DCS to diagnose vascular function in diabetes that was altered by acute and chronic hyperglycemic stress.

Conference Presentation

Citation Download Citation

Shotaro Sasaki, Mikie Nakabayashi, Yumie Ono, and Masashi Ichinose "Optical evaluation of microvascular function at early and chronic stages of diabetes", Proc. SPIE 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables, 112370R (21 February 2020); https://doi.org/10.1117/12.2545267

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