The penetration and movement of nanoparticles on membrane

Lianxin Xin; Zixuan Wang; Jian Zhao; Zachary Tyler; Hacene Boukari; Essaid Zerrad; Jun Ren

doi:10.1117/12.2544321

21 February 2020 The penetration and movement of nanoparticles on membrane

Lianxin Xin, Zixuan Wang, Jian Zhao, Zachary Tyler, Hacene Boukari, Essaid Zerrad, Jun Ren

Proceedings Volume 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII; 112560M (2020) https://doi.org/10.1117/12.2544321
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this study, we used GROMACS, a versatile package for performing molecular dynamics to simulate the interactions between different nanoparticles and Dipalmitoyl PhosPhatidyl Choline (DPPC) to understand the physical mechanisms that govern the interactions between nanoparticles and lipid membrane. Our simulations show the responses of the lipid bilayer to the nanoparticles, including the formation of an adsorbent layer on the nanoparticle surface, transmembrane ectopic movements and inconspicuous endocytosis of the nanoparticle by the membrane. Effects of the size of the nanoparticles, structural shape and charge state on the interaction and transport processes will be examined and summarized.

Citation Download Citation

Lianxin Xin, Zixuan Wang, Jian Zhao, Zachary Tyler, Hacene Boukari, Essaid Zerrad, and Jun Ren "The penetration and movement of nanoparticles on membrane", Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560M (21 February 2020); https://doi.org/10.1117/12.2544321

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