Longitudinal monitoring of dose-dependent hemodynamic responses to chemotherapy in rodent breast cancer models using diffuse optics

Regine Choe

doi:10.1117/12.2582015

5 March 2021 Longitudinal monitoring of dose-dependent hemodynamic responses to chemotherapy in rodent breast cancer models using diffuse optics

Regine Choe

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Proceedings Volume 11624, Visualizing and Quantifying Drug Distribution in Tissue V; 116240C (2021) https://doi.org/10.1117/12.2582015
Event: SPIE BiOS, 2021, Online Only

Abstract

Diffuse optics are deep-tissue non-invasive monitoring techniques that quantify total hemoglobin concentration, blood oxygen saturation and blood flow. Although many demonstrated that diffuse optics are sensitive to changes induced by neoadjuvant chemotherapy in human with breast cancer, the effects of chemotherapeutic drug type, dose, duration, and timing on longitudinal hemodynamic responses are still not well-established. To investigate these effects, we performed longitudinal monitoring of hemodynamic parameters on syngeneic rodent models of breast cancer treated with various chemotherapeutic drugs often used in the clinic. Various doses and combination were explored based on the clinically equivalent dose and median lethal dose.

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Regine Choe "Longitudinal monitoring of dose-dependent hemodynamic responses to chemotherapy in rodent breast cancer models using diffuse optics", Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 116240C (5 March 2021); https://doi.org/10.1117/12.2582015

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KEYWORDS

Hemodynamics

Breast cancer

Diffuse optical imaging

Tumor growth modeling

Blood circulation

Tissue optics

Human subjects

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