Longitudinal evolution of neurovascular coupling during stroke recovery

Smrithi Sunil; Sefik Evren Erdener; Sreekanth Kura; Jianbo Tang; Dmitry Postnov; Xiaojun Cheng; John Jiang; Kivilcim Kilic; David Boas

doi:10.1117/12.2578423

5 March 2021 Longitudinal evolution of neurovascular coupling during stroke recovery

Smrithi Sunil, Sefik Evren Erdener, Sreekanth Kura, Jianbo Tang, Dmitry Postnov, Xiaojun Cheng, John Jiang, Kivilcim Kilic, David Boas

Author Affiliations +

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162923 (2021) https://doi.org/10.1117/12.2578423
Event: SPIE BiOS, 2021, Online Only

Abstract

We present the use of intrinsic optical signal imaging to monitor the progression of ischemic stroke in the acute and chronic phases of recovery. An optimized mouse photothrombosis stroke model is used to induce stroke in the sensory forelimb area and longitudinal recovery is assessed using resting state functional connectivity as well as forelimb stimulation. These functional measures are then correlated with behavioral outcome assessed with a forelimb asymmetry test. Obtaining measures in both the acute and chronic phases of recovery will enable better interpretation of human functional neuroimaging stroke studies and allow their use in understanding acute stroke.

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Smrithi Sunil, Sefik Evren Erdener, Sreekanth Kura, Jianbo Tang, Dmitry Postnov, Xiaojun Cheng, John Jiang, Kivilcim Kilic, and David Boas "Longitudinal evolution of neurovascular coupling during stroke recovery", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 1162923 (5 March 2021); https://doi.org/10.1117/12.2578423

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KEYWORDS

Stroke recovery

Neurovascular coupling

Neuroimaging

Hemodynamics

Intrinsic optical signal imaging

Ischemic stroke

Sensors

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