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5 March 2021 Label-free high-sensitivity (bio)sensing with silicon structures and systems at the micro and nanoscale
Giuseppe Barillaro
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Proceedings Volume 11662, Frontiers in Biological Detection: From Nanosensors to Systems XIII; 116620K (2021) https://doi.org/10.1117/12.2579692
Event: SPIE BiOS, 2021, Online Only
Abstract
When dealing with sensing of (bio)molecules the length scale of targets may vary over more than 2 orders of magnitude moving from elementary ions and molecules (0.1 to 1 nm) to complex proteins and virus (1 to 100 nm). A number of technologies have been proposed to prepare fluidic structures and systems with length scales enabling an effective interaction with the specific molecular target. Among these, electrochemical micro and nano structuring of silicon is increasingly attracting attention at research level for biosensing and microfluidics. In this talk, state-of-the-art research on silicon nano-micro structures and systems prepared by electrochemical etching for high-sensitivity (bio)sensing, among which, interferometers for ultra-high-sensitivity ion measurements in water, optical platforms for point-of-care clinical diagnostics, drop-and-measure photonic crystal systems for in-field optical biosensing, microneedles for transdermal biosensing, is presented and discussed.
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Giuseppe Barillaro "Label-free high-sensitivity (bio)sensing with silicon structures and systems at the micro and nanoscale", Proc. SPIE 11662, Frontiers in Biological Detection: From Nanosensors to Systems XIII, 116620K (5 March 2021); https://doi.org/10.1117/12.2579692
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KEYWORDS
Silicon
Nanostructuring
Biosensing
Ions
Microfluidics
Photonic crystals
Proteins
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