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1 August 2021 Investigating the role of the “mechanical” deformation of Azobenzene molecules for biological control
Ismael Duchesne, Tigran Galstian, Filippo Fabbri, Luca Sorelli, Denis Rodrigue, Mario Fafard
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Proceedings Volume 11812, Molecular and Nano Machines IV; 118120A (2021) https://doi.org/10.1117/12.2595624
Event: SPIE Organic Photonics + Electronics, 2021, San Diego, California, United States
Abstract
Azobenzene molecules have attracted important interest for photodynamic drug release and therapy applications. Often, their impact on the environment is directly associated to the photoinduced mechanical deformation of the molecule (when transferring from its Trans form to the Cis form). In the present talk, we demonstrate that the chemical impact of this transformation (pH, toxicity, etc.) also must be considered. We shall describe our work on the development of an optical control method of biological membranes based on the photoisomerization process. On the example of E-coli bacteria, we shall show that the isomerization process can indeed be used to control their behavior, but the changes in pH and toxicity are also playing important roles. Interestingly, while there are still many open questions, our preliminary results point out on the possibility of controlling protonic pump channels in a selective way.
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Ismael Duchesne, Tigran Galstian, Filippo Fabbri, Luca Sorelli, Denis Rodrigue, and Mario Fafard "Investigating the role of the “mechanical” deformation of Azobenzene molecules for biological control", Proc. SPIE 11812, Molecular and Nano Machines IV, 118120A (1 August 2021); https://doi.org/10.1117/12.2595624
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KEYWORDS
Molecules
Molecular biology
Toxicity
Bacteria
Biomedical optics
Photodynamic therapy
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