Detection of lipid at video rate with spectroscopic transient-mode photo-thermal optical coherence tomography (TM-PT-OCT)

Mohammad Hossein Salimi; Martin Villiger; Nima Tabatabaei

doi:10.1117/12.2607635

7 March 2022 Detection of lipid at video rate with spectroscopic transient-mode photo-thermal optical coherence tomography (TM-PT-OCT)

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

Author Affiliations +

Proceedings Volume 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; 119480C (2022) https://doi.org/10.1117/12.2607635
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Transient-mode photothermal optical coherence tomography (TM-PT-OCT) is introduced as a high-speed and video rate implementation of PT-OCT. Here, the transient thermal response of samples to a low power PT laser pulsed excitation is interrogated through temperature-induced variations in the OCT phase signals. Results suggest that the proposed method enhances the PT-OCT imaging speed by more than two orders of magnitude compared to conventional PT-OCT with lockin detection. This enhancement not only enables video rate visualization of molecules of interest (MOI), but also opens the door for use of multiple PT lasers to perform spectroscopic PT-OCT for detection and differentiation of multiple MOI’s with distinct absorption spectra. To demonstrate feasibility, experimental results on detection and differentiation of lipid and collagen are presented and discussed.

Conference Presentation

Citation Download Citation

Mohammad Hossein Salimi, Martin Villiger, and Nima Tabatabaei "Detection of lipid at video rate with spectroscopic transient-mode photo-thermal optical coherence tomography (TM-PT-OCT)", Proc. SPIE 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, 119480C (7 March 2022); https://doi.org/10.1117/12.2607635

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