Nanobeam and Nanoneedle technology study new biomarker and single molecular interaction

Feng Liang; Zhongcong Xie

doi:10.1117/12.2607664

3 March 2022 Nanobeam and Nanoneedle technology study new biomarker and single molecular interaction

Feng Liang, Zhongcong Xie

Proceedings Volume 11976, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX; 1197606 (2022) https://doi.org/10.1117/12.2607664
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Isoflurane, sevoflurane, and desflurane have been shown to have different neurotoxic effects. However, the underlying mechanism at the single molecular level remains unknown. Isoflurane, sevoflurane, and desflurane can differently induce mitochondrial dysfunction and ATP synthase is the critical component of mitochondrial function. We, therefore, set out to assess whether different anesthetics can selectively impair the interaction of ADP and ATP synthase at a single molecular level. We also employed Nano needle platform measured Tau at threonine 217 (Tau-PT217) and 181 (Tau-PT181) as newly identified blood biomarkers of Alzheimer’s disease (AD).

Conference Presentation

Citation Download Citation

Feng Liang and Zhongcong Xie "Nanobeam and Nanoneedle technology study new biomarker and single molecular interaction", Proc. SPIE 11976, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX, 1197606 (3 March 2022); https://doi.org/10.1117/12.2607664

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