Processing of multimodal images for assessment of rare skin diseases

Emilija V. Plorina; Ainars Rudzitis; Norbert Kiss; Alexey Lihachev; Ilze Lihacova

doi:10.1117/12.2620919

24 May 2022 Processing of multimodal images for assessment of rare skin diseases

Emilija V. Plorina, Ainars Rudzitis, Norbert Kiss, Alexey Lihachev, Ilze Lihacova

Proceedings Volume 12146, Clinical Biophotonics II; 121460C (2022) https://doi.org/10.1117/12.2620919
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Abstract

Pseudoxanthoma elasticum and Fabry disease are rare multi-systemic diseases with characteristic skin manifestations. Their rarity and complicated diagnostic process causes disability, decreased quality of life, and increased medical costs for the patients before the diagnosis. Therefore, a new non-invasive diagnostic approach will be developed using multispectral imaging to analyze images of Pseudoxanthoma elasticum skin manifestations and angiokeratomas which are characteristic of Fabry disease. For image acquisition an imaging prototype will be used utilizing 526 nm, 663 nm and 964 nm multispectral LEDs for diffuse reflectance imaging and 405 nm LEDs for autofluorescence excitation, as well as Nuance camera with spectral range 450 – 950 nm. Spectral reflectance and autofluorescence images will be analyzed to determine informative/efficient parameters suitable for identification and diagnostics of rare diseases.

Citation Download Citation

Emilija V. Plorina, Ainars Rudzitis, Norbert Kiss, Alexey Lihachev, and Ilze Lihacova "Processing of multimodal images for assessment of rare skin diseases", Proc. SPIE 12146, Clinical Biophotonics II, 121460C (24 May 2022); https://doi.org/10.1117/12.2620919

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