Duodenal multi-wavelength photobiomodulation with light-emitting diode improves glycemic control and hepatic parameters in type 2 diabetes animal model

Jinhee Kwon; So Hee Kim; Do Hyun Park

doi:10.1117/12.2656421

14 March 2023 Duodenal multi-wavelength photobiomodulation with light-emitting diode improves glycemic control and hepatic parameters in type 2 diabetes animal model

Jinhee Kwon, So Hee Kim, Do Hyun Park

Author Affiliations +

Proceedings Volume 12362, Mechanisms of Photobiomodulation Therapy XVII; 1236207 (2023) https://doi.org/10.1117/12.2656421
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Emerging evidence in animal models suggests external photobiomodulation (PBM) improves glucose intolerance and insulin resistance. But data on therapeutic targets is limited. Recently, duodenum has been gaining attention to the therapeutic potential for metabolic disease including type 2 diabetes (T2DM). We investigated the role and underlying mechanism on the duodenal light emitting diode PBM whether this modality could lower serum glucose level and improve hepatic parameters in T2DM animal model. This study identifies single session of duodenal multi-wavelength light emitting diode PBM affects improving hyperglycemia and hepatic parameters through increased serum insulin level, decreased insulin resistance, enhanced expression of insulin the pancreas, and change of gut microbiome and, thus representing the duodenum as an attractive therapeutic target for T2DM.

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Jinhee Kwon, So Hee Kim, and Do Hyun Park "Duodenal multi-wavelength photobiomodulation with light-emitting diode improves glycemic control and hepatic parameters in type 2 diabetes animal model", Proc. SPIE 12362, Mechanisms of Photobiomodulation Therapy XVII, 1236207 (14 March 2023); https://doi.org/10.1117/12.2656421

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