Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy

Ryuji Asaoka; Hiroshi Kiyomatsu; Akihiro Jono; Masaki Takao; Takashi Katagiri; Yusuke Oshima

doi:10.1117/12.2650088

14 March 2023 Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy

Ryuji Asaoka, Hiroshi Kiyomatsu, Akihiro Jono, Masaki Takao, Takashi Katagiri, Yusuke Oshima

Author Affiliations +

Proceedings Volume 12363, Multiscale Imaging and Spectroscopy IV; 1236309 (2023) https://doi.org/10.1117/12.2650088
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Osteoarthritis is the most common disease in articular cartilage. Raman spectroscopy is a promising tool for early detection of degenerative changes in cartilage matrix. In this study, surgically resected humeral heads of 14 patients were subjected to pathological analysis using Raman spectroscopy with principal component analysis and hierarchical clustering analysis. In the result, Raman spectral data of each specimen were divided into three major cluster reflecting the alteration in molecular composition of cartilage matrix. We also found histological characteristics in the cluster, suggesting that Raman spectrum is a biomarker to determine the condition of the cartilage tissue.

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Ryuji Asaoka, Hiroshi Kiyomatsu, Akihiro Jono, Masaki Takao, Takashi Katagiri, and Yusuke Oshima "Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy", Proc. SPIE 12363, Multiscale Imaging and Spectroscopy IV, 1236309 (14 March 2023); https://doi.org/10.1117/12.2650088

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