Longitudinally detecting collagen progression within multicellular pancreatic tumor spheroids using polarization-sensitive optical coherence tomography (Conference Presentation)

Trisha I. Valerio; Feng Yan; Chen Wang; Qinggong Tang; Wei R. Chen

doi:10.1117/12.2651577

14 March 2023 Longitudinally detecting collagen progression within multicellular pancreatic tumor spheroids using polarization-sensitive optical coherence tomography (Conference Presentation)

Trisha I. Valerio, Feng Yan, Chen Wang, Qinggong Tang, Wei R. Chen

Author Affiliations +

Proceedings Volume 12380, Biophotonics and Immune Responses XVIII; 123800B (2023) https://doi.org/10.1117/12.2651577
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Common two-dimensional (2D) models are ineffective in mimicking solid tumors. Additionally, fibrotic stroma is one of the major characteristics of pancreatic tumors and it is often missing in in vitro models. Therefore, there is a need for a better in vitro model to accurately mimic the characteristics of tumor and to detect the progression of fibrosis within the tumor model. Here, we utilized polarization-sensitive optical coherence tomography (PS-OCT) to longitudinally detect the collagen progression within multicellular pancreatic tumor spheroids in vitro. Spheroids were scanned by PS-OCT every two days, and progression of fibrosis within the spheroids were detected.

Conference Presentation

Citation Download Citation

Trisha I. Valerio, Feng Yan, Chen Wang, Qinggong Tang, and Wei R. Chen "Longitudinally detecting collagen progression within multicellular pancreatic tumor spheroids using polarization-sensitive optical coherence tomography (Conference Presentation)", Proc. SPIE 12380, Biophotonics and Immune Responses XVIII, 123800B (14 March 2023); https://doi.org/10.1117/12.2651577

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KEYWORDS

Tumors

Collagen

Optical coherence tomography

Pancreatic cancer

3D modeling

Cancer

In vitro testing

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