Accuracy of uniform vs non-uniform shrinkage of intravascular imaging-based coronary plaque models for plaque structural stress estimations: validation against histology

Retesh Bajaj; Helle Precht; Mazen Abou Gamrah; Amear Souded Ali Jan Mohammed; Tom Johnson; Stephanie Grainger; Michael J. Hendricks; Lorenz Raber; Kit Mills Bransby; Anthony Mathur; Andreas Baumbach; Hector Garcia-Garcia; Alexander Broersen; Jouke Dijkstra; Ryo Torii; Christos Bourantas

doi:10.1117/12.3007278

13 March 2024 Accuracy of uniform vs non-uniform shrinkage of intravascular imaging-based coronary plaque models for plaque structural stress estimations: validation against histology

Retesh Bajaj, Helle Precht, Mazen Abou Gamrah, Amear Souded Ali Jan Mohammed, Tom Johnson, Stephanie Grainger, Michael J. Hendricks, Lorenz Raber, Kit Mills Bransby, Anthony Mathur, Andreas Baumbach, Hector Garcia-Garcia, Alexander Broersen, Jouke Dijkstra, Ryo Torii, Christos Bourantas

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Proceedings Volume 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024; 1281905 (2024) https://doi.org/10.1117/12.3007278
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Coronary artery plaque structural stress (PSS) is associated with plaque vulnerability and is quantifiable in vivo with optical coherence tomography (OCT) and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) but the accuracy of these is unclear. This study explored the performance of the two modalities in measuring PSS using histology as reference standard. NIRS-IVUS and OCT images obtained in vessels under physiological pressure require transformation to a zero-pressure condition to estimate PSS. Two methods were examined to achieve this – uniform and non-uniform shrinkage (which may to be superior for eccentric plaques) followed by PSS computation which was compared to histology-derived PSS. NIRS-IVUS and OCT imaging were conducted ex vivo in cadaveric human coronaries prior to histological analysis. In 93 pairs of NIRS-IVUS-histology and 88 pairs of OCT-histology sections, the correlation between the PSS estimated by histology and NIRS-IVUS using the uniform shrinkage approach was higher than that derived by OCT. Non-uniform shrinkage resulted in a numerically lower correlation but no significant difference by Bland-Altman analysis compared to uniform shrinkage.

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Retesh Bajaj, Helle Precht, Mazen Abou Gamrah, Amear Souded Ali Jan Mohammed, Tom Johnson, Stephanie Grainger, Michael J. Hendricks, Lorenz Raber, Kit Mills Bransby, Anthony Mathur, Andreas Baumbach, Hector Garcia-Garcia, Alexander Broersen, Jouke Dijkstra, Ryo Torii, and Christos Bourantas "Accuracy of uniform vs non-uniform shrinkage of intravascular imaging-based coronary plaque models for plaque structural stress estimations: validation against histology", Proc. SPIE 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024, 1281905 (13 March 2024); https://doi.org/10.1117/12.3007278

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KEYWORDS

Shrinkage

Optical coherence tomography

Finite element methods

Arteries

Data processing

Computer simulations

In vivo imaging

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