Photovoltaic restoration of sight in age-related macular degeneration

Daniel V. Palanker; Mohajeet B. Bhuckory; Bingyi Wang; Zhijie C. Chen; Andrew Shin; Nathan Jensen; Ludwig Galambos; Keith Mathieson; Theodore Kamins

doi:10.1117/12.3006243

13 March 2024 Photovoltaic restoration of sight in age-related macular degeneration

Daniel V. Palanker, Mohajeet B. Bhuckory, Bingyi Wang, Zhijie C. Chen, Andrew Shin, Nathan Jensen, Ludwig Galambos, Keith Mathieson, Theodore Kamins

Author Affiliations +

Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 1282907 (2024) https://doi.org/10.1117/12.3006243
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photovoltaic arrays implanted under the degenerated retina can convert light into pulsed electric current to stimulate the second-order retinal neurons for restoration of sight. Images captured by a camera are projected onto the retina from augmented-reality glasses using pulsed near-infrared light. Patients with such implants demonstrated consistent form perception with a letter acuity closely matching the 100um pixel size. Using current steering and 3-dimensional electrodes, pixels as small as 20um can stimulate the inner retina, providing grating acuity matching the pixel pitch, up to the natural resolution limit of 28um in rats. Optimization of these implants for human retina is in progress.

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Daniel V. Palanker, Mohajeet B. Bhuckory, Bingyi Wang, Zhijie C. Chen, Andrew Shin, Nathan Jensen, Ludwig Galambos, Keith Mathieson, and Theodore Kamins "Photovoltaic restoration of sight in age-related macular degeneration", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 1282907 (13 March 2024); https://doi.org/10.1117/12.3006243

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