The use of gold nanoparticles as a signal enhancer in LSPR for the detection of SARS-CoV-2

M. H. C. Tlomatsane; L. Thwala; Z. K. S. Mcotshana; S. Ombinda-Lemboumba; C. Williamson; P. Mthunzi-Kufa

doi:10.1117/12.3002379

12 March 2024 The use of gold nanoparticles as a signal enhancer in LSPR for the detection of SARS-CoV-2

M. H. C. Tlomatsane, L. Thwala, Z. K. S. Mcotshana, S. Ombinda-Lemboumba, C. Williamson, P. Mthunzi-Kufa

Proceedings Volume 12840, Optical Interactions with Tissue and Cells XXXV; 1284005 (2024) https://doi.org/10.1117/12.3002379
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The COVID-19 pandemic is a once-in-a-lifetime public health threat. The pandemic has had a significant impact on both individuals and communities’ health, safety, and well-being. Because COVID-19 is an extremely infectious and has nonspecific symptoms that are easily confused with the typical flu, it is critical to have precise diagnostic techniques readily available. There is an urgent need for quick detection of the SARS-CoV-2 virus due to the COVID-19 pandemic. Here, we present highly sensitive gold nanoparticle-enhanced localized surface plasmon resonance (LSPR) technique for detection of SARS-CoV-2 virus. Surface plasmon resonance is a powerful method for getting label-free, real-time information about the interaction of two binding partners. Gold nanoparticles (AuNPs) were used as signal enhancers in the diagnosis of SARS-CoV- 2 virus using the LSPR technique. Gold nanoparticles are stable against oxidation, great biocompatible, non-cytotoxic and have unique optical characteristics. These specific properties make AuNPs the most potential nanomaterial for different applications such as ultrasensitive detection and biological sensing.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

M. H. C. Tlomatsane, L. Thwala, Z. K. S. Mcotshana, S. Ombinda-Lemboumba, C. Williamson, and P. Mthunzi-Kufa "The use of gold nanoparticles as a signal enhancer in LSPR for the detection of SARS-CoV-2", Proc. SPIE 12840, Optical Interactions with Tissue and Cells XXXV, 1284005 (12 March 2024); https://doi.org/10.1117/12.3002379

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available