Exploring mucosal vaccination as an alternative to conventional vaccines

Xinru Li

doi:10.1117/12.3012823

8 January 2024 Exploring mucosal vaccination as an alternative to conventional vaccines

Xinru Li

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129242E (2024) https://doi.org/10.1117/12.3012823
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Vaccination has been instrumental in preventing and controlling the spread of infectious diseases for decades. Vaccination aims to trigger the immune system to generate a safeguarding reaction against a particular pathogen without inducing sickness. Advances in vaccination have led to the exploration of alternative administration routes beyond parenteral vaccination, which is often insufficient in stimulating immunity at the site where pathogens enter the body. Mucosal vaccination has been proposed as a more effective alternative as the mucosal immune response serves as the primary defense against a wide range of pathogens, thus conferring protection through mucosal immunity. Mucosal vaccines are easy to administer, cost-effective, non-invasive, and ideal for use in developing countries with limited medical resources. However, developing effective mucosal vaccines has proven challenging as they must be able to penetrate the mucosal barrier, withstand degradation by proteases, and effectively stimulate an immune response. This review provides a comprehensive introduction to the principles and applications of mucosal vaccines, including the challenges and potential strategies. The vaccine formulation, delivery method, and adjuvant selection are critical considerations in developing effective mucosal vaccines. The review highlights the potential of mucosal vaccines as a viable alternative to conventional vaccines, especially in the face of emerging infectious diseases.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Xinru Li "Exploring mucosal vaccination as an alternative to conventional vaccines", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129242E (8 January 2024); https://doi.org/10.1117/12.3012823

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KEYWORDS

Pathogens

Diseases and disorders

Antibodies

Attenuation

Digestive system

Absorption

COVID 19

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