UV plasmonics for enhancing the sensitivity and selectivity of neurotransmitter sensor based on their native fluorescence

Mohammad Mohammadi; Yunshan Wang

doi:10.1117/12.3028624

4 October 2024 UV plasmonics for enhancing the sensitivity and selectivity of neurotransmitter sensor based on their native fluorescence

Mohammad Mohammadi, Yunshan Wang

Author Affiliations +

Proceedings Volume 13115, UV and Higher Energy Photonics: From Materials to Applications 2024; 1311506 (2024) https://doi.org/10.1117/12.3028624
Event: Nanoscience + Engineering, 2024, San Diego, California, United States

Abstract

This study presents a biomolecule sensor utilizing ultraviolet plasmonic-enhanced native fluorescence, enhancing sensitivity and selectivity for detecting neurotransmitters (NTs). NTs, like monoamines, fluoresce weakly in the UV range. Plasmonic nanostructures, including Aluminum hole arrays, Aluminum nanocubes, and Al nanotriangles amplify UV fluorescence, and this biosensor improves NT detection, which is critical for understanding neurological disorders. Traditional methods lack multi-NT probing and molecule differentiation. Tested neurotransmitters include Tryptophan, Dopamine, Norepinephrine, and DOPAC. Multi-layered and monolayer silica microspheres increase sensitivity by 28 and 14 times compared to Si wafers. Furthermore, AL hole arrays and AL nanocubes could enhance the FL signal of three neurotransmitters (DA, NE, DOPAC) by 6 to 9 times. This paper highlights UV plasmonic-enhanced fluorescence's potential for distinguishing similar NT structures.

Conference Presentation

Citation Download Citation

Mohammad Mohammadi and Yunshan Wang "UV plasmonics for enhancing the sensitivity and selectivity of neurotransmitter sensor based on their native fluorescence", Proc. SPIE 13115, UV and Higher Energy Photonics: From Materials to Applications 2024, 1311506 (4 October 2024); https://doi.org/10.1117/12.3028624

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