Recent developments in quantitative phase-contrast microtomography using Talbot array illuminators

Dominik John; Mirko Riedel; Alex Gustschin; Sara Savatović; Alissa Breit; Fabio De Marco; Pidassa Bidola; Jörg U. Hammel; Julian Moosmann; D. C. Florian Wieland; Berit Zeller-Plumhoff; Felix Beckmann; Julia Herzen

doi:10.1117/12.3027345

23 October 2024 Recent developments in quantitative phase-contrast microtomography using Talbot array illuminators

Dominik John, Mirko Riedel, Alex Gustschin, Sara Savatović, Alissa Breit, Fabio De Marco, Pidassa Bidola, Jörg U. Hammel, Julian Moosmann, D. C. Florian Wieland, Berit Zeller-Plumhoff, Felix Beckmann, Julia Herzen

Author Affiliations +

Proceedings Volume 13152, Developments in X-Ray Tomography XV; 1315215 (2024) https://doi.org/10.1117/12.3027345
Event: Optical Engineering + Applications, 2024, San Diego, California, United States

Abstract

This study explores recent developments in quantitative phase-contrast microtomography using Talbot Array Illuminators (TAI) combined with Unified Modulated Pattern Analysis (UMPA). We first compare the performance of the TAI-based method for phase-retrieval with propagation-based imaging (PBI) for analyzing a Mg-10Gd bone implant sample that violates the single-material assumption. Our results demonstrate that the TAI method yields a significantly higher contrast-to-noise ratio (CNR) compared to PBI (101.68 vs. 54.37, an 87% improvement) while maintaining comparable edge sharpness. The TAI method also visualizes a substructure of the degradation layer, which appears comparatively blurred in the PBI images. Additionally, we introduce a hanging-rotation-axis approach for imaging paraffin-embedded samples in an ethanol bath, aiming to reduce edge enhancement artifacts caused by large electron density differences. Preliminary results indicate that the TAI-based images of a paraffin-embedded lymph node show improved uniformity in background intensity, though some additional low-frequency noise is observed. All experiments were conducted at the High Energy Materials Beamline (HEMS), PETRA III, DESY, operated by Hereon. Our findings highlight the potential of TAI-based phase-contrast imaging for complex, multi-material samples and suggest avenues for further optimization of the technique.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Dominik John, Mirko Riedel, Alex Gustschin, Sara Savatović, Alissa Breit, Fabio De Marco, Pidassa Bidola, Jörg U. Hammel, Julian Moosmann, D. C. Florian Wieland, Berit Zeller-Plumhoff, Felix Beckmann, and Julia Herzen "Recent developments in quantitative phase-contrast microtomography using Talbot array illuminators", Proc. SPIE 13152, Developments in X-Ray Tomography XV, 1315215 (23 October 2024); https://doi.org/10.1117/12.3027345

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