Photoacoustic imaging of the liver in mice with minimal hepatic encephalopathy

Mingdong Xie; Sanmu Li; Zhihong Zhang; Yanfeng Dai

doi:10.1117/12.3057939

10 January 2025 Photoacoustic imaging of the liver in mice with minimal hepatic encephalopathy

Mingdong Xie, Sanmu Li, Zhihong Zhang, Yanfeng Dai

Author Affiliations +

Proceedings Volume 13507, Seventeenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2024); 1350703 (2025) https://doi.org/10.1117/12.3057939
Event: Seventeenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2024), 2024, Shaya, China

Abstract

Minimal Hepatic Encephalopathy (MHE) is a potential neurological complication in patients with liver cirrhosis. Here, we propose the use of Photoacoustic Imaging (PAI) for non-invasive assessment of the structure and function of the liver in MHE. Our PAI results showed that the hepatic vascular structure in the acute MHE mice model did not undergo significant changes, but the hemoglobin oxygen saturation content was markedly decreased. In contrast, in the chronic MHE model, the hepatic vasculature of the mice was disorganized, and the architecture of the hepatic lobule was not intact, and the liver function of hepatic metabolism was also significantly impaired. This study has demonstrated that PAI holds immense potential to assess liver structure and function in MHE disease.

(2025) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mingdong Xie, Sanmu Li, Zhihong Zhang, and Yanfeng Dai "Photoacoustic imaging of the liver in mice with minimal hepatic encephalopathy", Proc. SPIE 13507, Seventeenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2024), 1350703 (10 January 2025); https://doi.org/10.1117/12.3057939

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KEYWORDS

Liver

Photoacoustic imaging

Photoacoustic tomography

Biological imaging

Photoacoustic spectroscopy

Animals

Magnetic resonance imaging

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