Evaluation of multidirectional fluorescence-sensing laser catheter for the development of an intelligent laser angioplasty system

Takayuki Asahara M.D.; Mikio Usui M.D.; Takashi Amemiya M.D.; Yasuhisa Oike M.D.; Hiromori Shiraishi M.D.; Manabu Miyagi; Hitoshi Nakajima; Tomitsugu Kato M.D.; Yuichi Naito M.D.; Chiharu Ibukiyama M.D.; Katsuo Aizawa; Hiromi Tominaga; Isako Hoshino

doi:10.1117/12.146590

23 June 1993 Evaluation of multidirectional fluorescence-sensing laser catheter for the development of an intelligent laser angioplasty system

Takayuki Asahara M.D., Mikio Usui M.D., Takashi Amemiya M.D., Yasuhisa Oike M.D., Hiromori Shiraishi M.D., Manabu Miyagi, Hitoshi Nakajima, Tomitsugu Kato M.D., Yuichi Naito M.D., Chiharu Ibukiyama M.D., Katsuo Aizawa, Hiromi Tominaga, Isako Hoshino

Author Affiliations +

Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993) https://doi.org/10.1117/12.146590
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The differential diagnostic capacity of a multi-directional sensing catheter with intraluminal objects was evaluated by fluorescence analysis following administration of a photosensitizer. The measurement catheter is 1.7 mm in diameter and is constructed with a cross-sectional arrangement of 6 sensor bundle units and a centered guide wire lumen. Fluorescence was analyzed by polychrometer and amplified CCD camera with an image intensifier. The excitation light was 405 nm wavelength obtained from an Xe-Hg lamp using a band pass filter. In vivo and in vitro fluorescence analysis of normal and atherosclerotic rabbit aorta was performed following intravenous administration of 5 mg/kg hematoporphyrin derivatives (HpD) 24 hours before. The multi-directional sensing catheter detected fluorescence spectra independently in real time. In vivo measurement of this catheter showed, relative to the tip of catheter, in which direction there was blood, normal intima, slight intimal thickness, which should not be treated by laser, or areas of atherosclerosis, which can be treated by laser.

Citation Download Citation

Takayuki Asahara M.D., Mikio Usui M.D., Takashi Amemiya M.D., Yasuhisa Oike M.D., Hiromori Shiraishi M.D., Manabu Miyagi, Hitoshi Nakajima, Tomitsugu Kato M.D., Yuichi Naito M.D., Chiharu Ibukiyama M.D., Katsuo Aizawa, Hiromi Tominaga, and Isako Hoshino "Evaluation of multidirectional fluorescence-sensing laser catheter for the development of an intelligent laser angioplasty system", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); https://doi.org/10.1117/12.146590

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available