Photodynamic effects on T-cells and skin lesions of a patient with mycosis fungoides using porphyrin photosensitizers

Karsten Koenig; Wolf-Henning Boehncke; Angelika C. Rueck; Roland Kaufmann; Rudolf W. Steiner; Wolfram Sterry

doi:10.1117/12.169144

15 February 1994 Photodynamic effects on T-cells and skin lesions of a patient with mycosis fungoides using porphyrin photosensitizers

Karsten Koenig, Wolf-Henning Boehncke, Angelika C. Rueck, Roland Kaufmann, Rudolf W. Steiner, Wolfram Sterry

Author Affiliations +

Proceedings Volume 2086, Medical Applications of Lasers; (1994) https://doi.org/10.1117/12.169144
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

PUVA is a well established phototreatment modality for various dermatoses, like T cell lymphomas, using long-wavelength UV radiation. In contrast, PDT bases on the combination of photosensitizers, especially porphyrins, and radiation mainly in the red spectral region. We analyzed the photochemical effects of both treatments on cell lines MyLa and HuT78, established from patients with cutaneous T cell lymphomas. Our observations document the capability of PDT to inhibit proliferation of transformed T cells similar to PUVA thus pointing out its potential in the treatment of cutaneous T cell lymphomas.

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Karsten Koenig, Wolf-Henning Boehncke, Angelika C. Rueck, Roland Kaufmann, Rudolf W. Steiner, and Wolfram Sterry "Photodynamic effects on T-cells and skin lesions of a patient with mycosis fungoides using porphyrin photosensitizers", Proc. SPIE 2086, Medical Applications of Lasers, (15 February 1994); https://doi.org/10.1117/12.169144

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