New technique for prostatectomy using Ho:YAG laser

Yuichiro Daidoh M.D.; Tsunenori Arai; Masaru Murai M.D.; Akio Nakajima; Akira Tsuji; Kunio Odajima; Fumio Nakajima; Makoto Kikuchi; Hiroshi Nakamura M.D.

doi:10.1117/12.175024

2 May 1994 New technique for prostatectomy using Ho:YAG laser

Yuichiro Daidoh M.D., Tsunenori Arai, Masaru Murai M.D., Akio Nakajima, Akira Tsuji, Kunio Odajima, Fumio Nakajima, Makoto Kikuchi, Hiroshi Nakamura M.D.

Author Affiliations +

Proceedings Volume 2129, Lasers in Urology; (1994) https://doi.org/10.1117/12.175024
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

To develop a new transperineal laser prostatectomy through a biopsy needle, we determined the efficiency of a pulsed Nd:YAG laser irradiation for canine prostate. The Ho:YAG laser ((lambda) equals 2.1 micrometers ) may induced stress-wave to destroy the small vessels in prostate. After the exposure of the canine prostate, it was punctured by the needle. A quartz fiber of which core-diameter was 200 or 400 micrometers was inserted into the 18 G needle. The irradiation fluence was set to 150 - 600 J/cm² and repetition rate was kept at 2 Hz. The cross-section of the irradiated portion of the prostate extracted immediately after the irradiation showed dark-colored hemorrhage layer around the ablation tract with 1 - 2 mm thickness. Some hemorrhage was histologically seen in stoma and gland in the irradiated prostate. In the case of 150 - 175 J/cm² in the irradiation fluence, the irradiated portion of the prostate was found in the wedge-shaped area with brown color at one week after the irradiation. The lymphocytes infiltrating into the wedge-shaped zone were found. The wedge- shaped zone spread over the prostate and the change of urethral mucosa was minimum at one month after the irradiation. In the case of 500 - 600 J/cm² irradiation, the paraurethral cavity was made at one month after the irradiation. The histological examination showed that the hemorrhage and subsequent histological changes may be caused by the laser induced stress-wave rather than thermal effect. Our results suggest that transperineal irradiation of pulsed Ho:YAG might offer an effective treatment for benign prostatic hyperplasia with the minimal damage to the urethral mucosa.

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Yuichiro Daidoh M.D., Tsunenori Arai, Masaru Murai M.D., Akio Nakajima, Akira Tsuji, Kunio Odajima, Fumio Nakajima, Makoto Kikuchi, and Hiroshi Nakamura M.D. "New technique for prostatectomy using Ho:YAG laser", Proc. SPIE 2129, Lasers in Urology, (2 May 1994); https://doi.org/10.1117/12.175024

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KEYWORDS

Prostate

Laser irradiation

Laser therapeutics

Quartz

Biopsy

Laser ablation

Pulsed laser operation

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