Fluorescence imaging of early lung cancer

Stephen Lam; Calum E. MacAulay; Jean C. Le Riche; Norihiko Ikeda; Branko Palcic

doi:10.1117/12.198716

4 January 1995 Fluorescence imaging of early lung cancer

Stephen Lam, Calum E. MacAulay, Jean C. Le Riche, Norihiko Ikeda, Branko Palcic

Author Affiliations +

Proceedings Volume 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging; (1995) https://doi.org/10.1117/12.198716
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The performance of a fluorescence imaging device was compared with conventional white-light bronchoscopy in 100 patients with lung cancer, 46 patients with resected State I nonsmall cell lung cancer, 10 patients with head and neck cancer, and 67 volunteers who had smoked at least one pack of cigarettes per day for twenty-five years or more. Using differences in tissue autofluorescence between premalignant, malignant and normal tissues, fluorescence bronchoscopy was found to detect more than twice as many moderate-severe dysplasia and carcinoma in situ sites than conventional white-light bronchoscopy. The use of fluorescence imaging to detect small peripheral lung nodules was investigated in a micro metastatic lung model of mice implanted with Lewis lung tumor cells. Fluorescence imaging was found to be able to detect small malignant lung lesions. The use of (delta) -aminolevulinic acid (ALA) to enhance fluorescence detection of CIS was investigated in a patient after oral administration of 60 mg/kg of ALA four hours prior to bronchoscopy, although ALA enhanced the tumor's visibility, multiple sites of false positive fluorescence were observed in areas of inflammation or metaplasia.

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Stephen Lam, Calum E. MacAulay, Jean C. Le Riche, Norihiko Ikeda, and Branko Palcic "Fluorescence imaging of early lung cancer", Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); https://doi.org/10.1117/12.198716

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