Sensing a heart infarction marker with surface plasmon resonance spectroscopy

Ulrich Kunz; Andreas Katerkamp; Reinhard Renneberg; Friedrich Spener; Karl Cammann

doi:10.1117/12.201250

10 February 1995 Sensing a heart infarction marker with surface plasmon resonance spectroscopy

Ulrich Kunz, Andreas Katerkamp, Reinhard Renneberg, Friedrich Spener, Karl Cammann

Author Affiliations +

Proceedings Volume 2331, Medical Sensors II and Fiber Optic Sensors; (1995) https://doi.org/10.1117/12.201250
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

In this study a direct immunosensor for heart-type fatty acid binding protein (FABP) based on surface plasmon resonance spectroscopy (SPRS) is presented. FABP can be used as a heart infarction marker in clinical diagnostics. The development of a simple and cheap direct optical sensor device is reported in this paper as well as immobilization procedures and optimization of the measuring conditions. The correct working of the SPRS device is controlled by comparing the signals with theoretical calculated values. Two different immunoassay techniques were optimized for a sensitive FABP-analysis. The competitive immunoassay was superior to the sandwich configuration as it had a lower detection limit (100 ng/ml), needed less antibodies and could be carried out in one step.

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Ulrich Kunz, Andreas Katerkamp, Reinhard Renneberg, Friedrich Spener, and Karl Cammann "Sensing a heart infarction marker with surface plasmon resonance spectroscopy", Proc. SPIE 2331, Medical Sensors II and Fiber Optic Sensors, (10 February 1995); https://doi.org/10.1117/12.201250

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