Broadband fiber optic interferometry: diagnostics by depth profiling of optical properties of biological media

Scott C. Shukes; Robert Splinter; Faramarz Farahi; M. Yasin Akhtar Raja; G. A. Nanney; K. R. Dezern; Michelle Thompson; George P. Tatsis

doi:10.1117/12.208393

1 May 1995 Broadband fiber optic interferometry: diagnostics by depth profiling of optical properties of biological media

Scott C. Shukes, Robert Splinter, Faramarz Farahi, M. Yasin Akhtar Raja, G. A. Nanney, K. R. Dezern, Michelle Thompson, George P. Tatsis

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Proceedings Volume 2396, Biomedical Optoelectronic Instrumentation; (1995) https://doi.org/10.1117/12.208393
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Although non-invasive methods for in-situ analysis of laser-tissue interaction are not available yet, it continues to be an area of increased interest owing to its potential. This paper describes the development of an integrated diagnostic and therapeutic laser procedure through in-situ monitoring of the optical tissue characteristics in a non-invasive manner. Biological tissues are highly scattering media. The system under development uses a broadband (white-light) interferometer that derives the scattered signals obtained from different depths of the biological medium. The tissue light signature obtained in this manner will be curve fitted to the appropriate computer simulation resulting from the optical properties particular to well defined tissues, resulting from simulations within a range of optical parameters. The beam profile of the irradiation source appears to affect the ability to distinguish between certain tissues. A single mode fiber in tissue contact produces a statistically significant different light signature for at least three myocardial tissues. However, the theoretical resolution is limited to 4 to 8 mm depth. Identification of the local optical characteristics will provide discrimination between healthy and pathological conditions in addition to real time assessment of dosimetry.

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Scott C. Shukes, Robert Splinter, Faramarz Farahi, M. Yasin Akhtar Raja, G. A. Nanney, K. R. Dezern, Michelle Thompson, and George P. Tatsis "Broadband fiber optic interferometry: diagnostics by depth profiling of optical properties of biological media", Proc. SPIE 2396, Biomedical Optoelectronic Instrumentation, (1 May 1995); https://doi.org/10.1117/12.208393

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KEYWORDS

Tissue optics

Tissues

Interferometers

Computer simulations

Fiber optics

Laser tissue interaction

Geometrical optics

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