Results and survival after photodynamic therapy in early-stage esophageal carcinoma

Pasquale Spinelli; Andrea Mancini; Marco Dal Fante; Emmanuele Meroni; Algirdas Jasinskas

doi:10.1117/12.230363

19 January 1996 Results and survival after photodynamic therapy in early-stage esophageal carcinoma

Pasquale Spinelli, Andrea Mancini, Marco Dal Fante, Emmanuele Meroni, Algirdas Jasinskas

Author Affiliations +

Proceedings Volume 2623, Medical Applications of Lasers III; (1996) https://doi.org/10.1117/12.230363
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

From January 1985 to December 1994, 23 early stage carcinomas of the esophagus were treated by photodynamic therapy in 21 patients. The stage of the tumors was assessed by esophagoscopy with multiple biopsies, CT scan and, from June 1991, also by endoscopic ultrasonography: 7 lesions were classified as carcinoma in situ (Tis) and 16 as invasive (T1). The photosensitizers used for PDT were hematoporphyrin derivative 3 mg/kg in 4 patients and dihematoporphyrin ether 2 mg/kg in 17. Light irradiation was performed using an Argon-dye laser system at a wavelength of 630 nm with an average energy of 50 J/cm² and 70 J/cm² for the treatment of Tis and T1, respectively. A complete response was achieved in 17/23 (74%) tumors, 15/21 (71%) patients. In the follow-up period from 6 to 78 months (median 36 months) 3 recurrences occurred 6, 12, and 14 months after PDT, respectively. Seven patients died due to concomitant diseases, not related to tumor progression. The actuarial survival rate was 95%, 75% and 37% at 1, 3, and 5 years, respectively. Complications included 1 case of sunburn and 2 cases of esophageal stenosis at the treatment site, that gradually responded to endoscopic bougienage.

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Pasquale Spinelli, Andrea Mancini, Marco Dal Fante, Emmanuele Meroni, and Algirdas Jasinskas "Results and survival after photodynamic therapy in early-stage esophageal carcinoma", Proc. SPIE 2623, Medical Applications of Lasers III, (19 January 1996); https://doi.org/10.1117/12.230363

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