Electromagnetic simulation of laser-induced fluorescence in bronchial tissue and predicted optical scattering behavior

Karl J. Bamford; Jim James; Hugh Barr M.D.; Ralph P. Tatam

doi:10.1117/12.339190

12 February 1999 Electromagnetic simulation of laser-induced fluorescence in bronchial tissue and predicted optical scattering behavior

Karl J. Bamford, Jim James, Hugh Barr M.D., Ralph P. Tatam

Author Affiliations +

Proceedings Volume 3567, Optical and Imaging Techniques for Biomonitoring IV; (1999) https://doi.org/10.1117/12.339190
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

Previous measurement by Qu et al, of laser-induced fluorescence in bronchus tissue are simulated using an electromagnetic (EM) scattering model. The EM parameters derived indicate that the changes in the epithelium thickness with carcinoma in situ can be detected with an optical radar process, hence providing an early detection of cancer. Further simulation using the EM model indicates various practical methods of extracting the thickness changes. These include frequency modulated continuous wave optical radar, multilaser continuous wave radar and low coherence interferometry. Initial optical experiments and calculations clarify which method is likely to lead to the development of endoscope instrumentation, but the availability of suitable optical components is a major consideration. Some early interferometry results indicate that a resolution of at least 40 micrometers can be readily reached for histological imaging. For 10 micrometers cell resolution, additional techniques are required.

Citation Download Citation

Karl J. Bamford, Jim James, Hugh Barr M.D., and Ralph P. Tatam "Electromagnetic simulation of laser-induced fluorescence in bronchial tissue and predicted optical scattering behavior", Proc. SPIE 3567, Optical and Imaging Techniques for Biomonitoring IV, (12 February 1999); https://doi.org/10.1117/12.339190

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