Optically programmable assembly of ordered bead arrays: a novel technology for on-chip biochemical analysis

Chiu Chau; Sukanta Banerjee; Michael Seul

doi:10.1117/12.359352

19 August 1999 Optically programmable assembly of ordered bead arrays: a novel technology for on-chip biochemical analysis

Chiu Chau, Sukanta Banerjee, Michael Seul

Author Affiliations +

Proceedings Volume 3877, Microfluidic Devices and Systems II; (1999) https://doi.org/10.1117/12.359352
Event: Symposium on Micromachining and Microfabrication, 1999, Santa Clara, CA, United States

Abstract

We describe an optically programmable bead array assembly process and its efficient implementation. Invoking our core technology of light-controlled electrokinetic assembly of particles near surfaces, this process enables the on-demand assembly and real-time manipulation of planar arrays of microparticles (`beads') within a small reaction chamber in response to electric fields and in accordance with computer- generated patterns of illumination. We are integrating this array fabrication process with proprietary microfluidics and image acquisition in a palmtop bioanalytical microlab to provide a general-purpose platform for a highly parallel assay format in which tens to thousands of biochemical tests (`assays') can be performed simultaneously on the surface of a semiconductor chip. Applications include the quantitative analysis of protein-protein interactions and DNA hybridization as well as cellular analysis.

Citation Download Citation

Chiu Chau, Sukanta Banerjee, and Michael Seul "Optically programmable assembly of ordered bead arrays: a novel technology for on-chip biochemical analysis", Proc. SPIE 3877, Microfluidic Devices and Systems II, (19 August 1999); https://doi.org/10.1117/12.359352

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